4DGENOME, INC
SERVICES
haplotyping by single-chromosome sequencing
4DGenome is leading technology company, providing microbiome, single cell, single chromosome, low input whole genome sequencing service. We also offer customized bioinformatics service. Let us provide you with the personalized service you deserve.
TECHNOLOGY
We isolate single chromosomes and sequence them individually.
ISOLATE ONE CHROMOSOME BY COMPUTER-DIRECTED LASER MICRODISSECTION
ISOLATE THREE SINGLE CHROMOSOMES BY COMPUTER-DIRECTED LASER MICRODISSECTION
AN ILLUSTRATION OF THE GENERAL SEQUENCE PIPELINE
SCIENCE&EDUCATION
1. WHAT IS A HAPLOTYPE?
The term haplotype was invented about 50 years ago by the Italian geneticist Ruggero Ceppellini (Milan, 1917 – 1988). Now the term and concept have been widely used since, long before DNA analysis. Human genomes are diploid. Human diploid cells contain two sets of homologous chromosomes, which have slightly different sequences from each other. Their complete description and interpretation require to know not only their mutations but also the arrangement of these mutations onto chromosomal haplotypes. A haplotype is a sequence (or a collection of mutation) of each of those two homologous chromosomes. A haplogroup is a group of similar haplotypes that share common ancestors.
2.  WHY NEED CHROMOSOMAL HAPLOTYPES?
It is because two homologous chromosomes have different mutations, are functioning differently, their functionalities are closely related to their combinatorial content of mutations, and their functionalities are closely related to human diseases.
3.  WHY NEED TO MEASURE THE HAPLOTYPES EXPERIMENTALLY?
It is because it is much more accurate with less switch errors on long-range or chromosomal-range of haplotyping.
4.  WHO NEED HAPLOTYPES?
Disease-gene discovery
Rare diseases and rare mutations
long range eQTLs
Genetic epidemiological studies (association studies, linkage studies)
Functional interpretation of various high-throughput data sets
Linkage disequilibrium assessment
Genetic demography
HLA typing
Ancestry analysis
Evolution
Population history
Pharmaceutical companies
Hospitals
Agriculture
COMPANY
Get to Know Us a Bit Better
Since its founding in 2014, 4DGenome has been at the forefront of experimental haplotype determination and bioinformatics. Our goal is to offer high-quality products and service to meet your needs on haplotype sequencing and associated bioinformatic analysis. 4DGenome is located in Atlanta, Georgia, about 10 miles north from downtown Atlanta. Quality, satisfaction, and user friendly is our key to operations at 4DGenome.